As the focus of this text is on innate immunity, we limit our discussion of your prospective therapeutic implications of MIF to sepsis and ARDS.

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learned while in the late sixties as a product of activated T cells, the cytokine macrophage migration inhibitory factor (MIF) has actually been uncovered not too long ago to carry out essential functions as being a mediator in the innate immune program.

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MIF and host responses to other pathogens. Along with bacterial sepsis, MIF has been implicated from the pathogenesis of parasitic (malaria, cysticercosis and leishmaniasis) and viral (cytomegalovirus and influenza virus) bacterial infections. MIF is developed during the lymph nodes of mice contaminated with Leishmania big, and in vivo administration of recombinant MIF reduced the severity of infection67. Mice that lack Mif ended up far more liable to leishmaniasis and cysticercosis than wild-type mice68,sixty nine.

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